For sufferers with persistent ache, ineffective remedies, lowered work productiveness, and different elements usually coalesce, fueling emotions of hopelessness and nervousness and setting the stage for even larger issues, together with substance use issues. In 2017 alone, some 18 million Americans misused prescription ache relievers over the course of the earlier 12 months. In many of those cases, sufferers affected by persistent ache turned hooked on prescription opioids.
In addition to being extremely addictive, many research counsel that prescription opioids don’t successfully management ache over the long run, and therefore researchers have been exploring varied options, together with cannabidiol (CBD). CBD is a non-psychoactive substance derived from the Cannabis plant.
Studies have proven that whereas CBD reduces ache sensation in animals, its means to take action in people is restricted by low bioavailability, the extent to which the drug efficiently reaches its web site of motion. Now, new work by scientists on the Lewis Katz School of Medicine at Temple University suggests this impediment could also be overcome by a novel CBD analog often known as KLS-13019.
“In a mouse model of chemotherapy-induced peripheral neuropathy (CIPN), we’ve been able to show for the first time that KLS-13019 works as well as, if not better than, CBD in preventing the development of neuropathy and reversing pain sensitivity after pain has been established,” stated Sara Jane Ward, PhD, Assistant Professor of Pharmacology on the Katz School of Medicine and senior investigator on the brand new examine. The findings had been printed on-line April 6 within the British Journal of Pharmacology.
KLS-13019, developed by the Pennsylvania-based bio-pharmaceutical and phyto-medical firm Neuropathix, Inc., is among the many most promising neuroprotective CBD analogs presently underneath investigation. In earlier work in cell fashions, it was discovered to be stronger than CBD, and research in animals recommended it had improved bioavailability.
Encouraged by these preliminary research, Dr. Ward and colleagues got down to higher perceive the pain-relieving capabilities of KLS-13019, relative to CBD, in animals with CIPN. CIPN is a standard aspect impact of sure most cancers remedies that harm peripheral nerves, which carry sensory info to the arms, legs, and mind. The extreme ache, or peripheral neuropathy, brought on by CIPN manifests in numerous methods in human sufferers however continuously entails tingling or burning sensations and numbness, weak point, or discomfort within the limbs.
In a sequence of experiments designed to gauge animals’ ache responses, the researchers discovered that ache sensitivity was tremendously diminished in animals with CIPN that had been handled with KLS-13019 or CBD. KLS-13019 additional reversed sensitivity to painful stimuli in animals through which peripheral neuropathy was already established, an impact that was not noticed in CBD-treated animals.
Earlier research have additionally hinted on the chance that CBD is ready to cut back opioid craving in sufferers with opioid use dysfunction.
“Many patients who use opioids for pain management enter a cycle of reinforcement, where each use of opioids triggers reward pathways and perceived pain relief, leading to addiction,” Dr. Ward defined.
While Dr. Ward and colleagues didn’t discover proof supporting a job for CBD in lowering opioid craving, they did observe considerably diminished opioid-seeking habits in KLS-13019-treated animals.
“This tells us that KLS-13019 has benefits beyond its ability to alleviate pain,” Dr. Ward stated.
The researchers suspect that whereas doubtless sharing a mechanism with CBD for ache aid, KLS-13019 could have a further mechanism of motion, one which breaks up the pathways reinforcing opioid use.
In future work, Dr. Ward and her workforce plan to discover the mechanisms by which KLS-13019 exerts its results, notably these underlying the drug’s means to disrupt opioid-seeking habits. They additionally plan to check the power of KLS-13019 to alleviate different sorts of ache, past CIPN.
Other researchers who contributed to the examine embody Jeffery D. Foss, Daniel J. Farkas, and Lana M. Huynh, Center for Substance Abuse Research on the Katz School of Medicine, and William A. Kinney and Douglas E. Brenneman, Neuropathix, Inc., Pennsylvania Biotechnology Center, Doylestown, Pennsylvania.
The analysis was funded partially by National Institutes of Health grant R41 DA044898-01.